angiotensin converting enzyme 2 – Communicable Diseases Research

What do we know about the renin angiotensin system and inflammatory bowel disease?

Review

Published on 2022-10-012023-07-11
Journal: Expert opinion on therapeutic targets
[Category] COVID19(2023년),

On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus

바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화

Article

Published on 2022-08-152022-09-11
Journal: Journal of hazardous materials
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Stress response. Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus
[DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article

In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology

역백신학을 이용한 오미크론 균주에 대한 In silico SARS-CoV-2 백신 개발

Article

Published on 2022-08-012022-09-11
Journal: Genes & genomics
[Category] COVID19(2023년), SARS, 변종,

[키워드] 3D structure 3D Structures ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergenicity angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antigenic antigenicity applied B cell epitope B cell epitopes B.1.1.529 binding collected coronavirus develop Efficacy effort enzyme epitope Epitopes estimation final vaccine construct Health Organization in silico MHC I MHC II molecular docking analysis Mutation non-allergenic non-toxic omicron pandemic Physicochemical properties physicochemical property predict predicted Prevent profile RaptorX reduce reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccine second secondary structure secondary structures selected severe acute respiratory syndrome Coronavirus solubility Spread stability Structure tested the vaccine Toxicity Vaccine vaccine candidate vaccine construct Vaccine design Vaccine design. Vaccines variant viral genome sequences virus VoC was performed were used WHO wild type World Health Organization
[DOI] 10.1007/s13258-022-01255-8 PMC 바로가기 [Article Type] Article

Tissue repair strategies: What we have learned from COVID-19 in the application of MSCs therapy

Review article

Published on 2022-08-012022-10-05
Journal: Pharmacological research
[Category] 바이오마커, 변종, 임상, 치료제,

[키워드] ACE2angiotensin converting enzyme 2 acute lung injury acute respiratory distress syndrome adverse outcome ALIacute lung injury alveolar type 2 cells angiotensin converting enzyme 2 ARDSacute respiratory distress syndrome AstraZeneca AT2salveolar type 2 cells ataxia telangiectasia and Rad3-related ATRataxia telangiectasia and Rad3-related BDNFbrain derived neurotrophic factor brain derived neurotrophic factor BRDbromodomain protein bromodomain protein C-reactive protein CCNG1Cyclin G1 CD147cluster of differentiation 147 Cell Clinical finding cluster of differentiation 147 confirmed case Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients COVID-19coronavirus disease 2019 CRPC-reactive protein Cyclin G1 Cytokine storm DRP1dynamin-related protein 1 dynamin-related protein 1 ECMOextracorporeal membrane oxygenation effective EGFepidermal growth factor Emergency use authorization epidermal growth factor EUAemergency use authorization EVsextracellular vesicles example exhibited Extracellular vesicles extracorporeal membrane oxygenation FGFfibroblast growth factor fibroblast growth factor galanin and gmap prepropeptide GALgalanin and gmap prepropeptide GM-CSFgranulocyte macrophage-colony stimulating factor granulocyte macrophage-colony stimulating factor HBVHepatitis B virus Heme oxygenase-1 Hepatitis B virus hepatocyte growth factor hESCshuman embryonic stem cells HGFhepatocyte growth factor hiPSCshuman induced PSCs HIVhuman immunodeficiency virus HO-1heme oxygenase-1 hPSC-CMshPSC-derived cardiomyocytes hPSC-derived cardiomyocytes hPSCshuman pluripotent stem cells human embryonic stem cells Human immunodeficiency virus human induced PSCs human pluripotent stem cells Hyperinflammatory syndrome IFN-βinterferon-β IFN-γinterferon-γ IFN-λinterferon-λ IGF1Rinsulin like growth factor 1 receptor Infection insulin like growth factor 1 receptor Intensive Interferon-β interferon-γ interferon-λ keratinocyte growth factor-2 KGF2keratinocyte growth factor-2 leukemia inhibitory factor LIFleukemia inhibitory factor management MECP2methyl-CpG binding protein 2 Mesenchymal stem cells methyl-CpG binding protein 2 Microvesicles Moderna Mortality MSCs MSCs therapy MSCsmesenchymal stem cells MVsmicrovesicles National Institutes of Health nerve growth factor NGFnerve growth factor NIHNational Institutes of Health nitric oxide associated 1 NLR family pyrin domain containing 3 NLRP3NLR family pyrin domain containing 3 NOA1nitric oxide associated 1 organ damage organ injury P4HA1prolyl 4-hydroxylase subunit alpha 1 PDGFplatelet-derived growth factor Pfizer PGE2prostaglandin E2 phosphatase and tensin homolog platelet-derived growth factor Preclinical Preferred reporting items for systematic reviews and meta-analyses PRISMAPreferred reporting items for systematic reviews and meta-analyses proinflammatory prolyl 4-hydroxylase subunit alpha 1 prostaglandin E2 PTENphosphatase and tensin homolog Pulmonary infection Randomized controlled trial RCTrandomized controlled trial S-proteinspike protein SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SEMA3Asemaphorin 3 A semaphorin 3 A severe acute respiratory syndrome coronavirus 2 sialyl Lewis X signal transducer and activator of transcription 3 SLeXsialyl Lewis X Spike protein spread of COVID-19 STAT3signal transducer and activator of transcription 3 stem cell TGF-β1transforming growth factor β1 TGFBR1transforming growth factor β receptor I Therapies therapy tissue regeneration TLR4toll-like receptors 4 TMPRSS2transmembrane protease serine protease 2 TNFTumor Necrosis Factor toll-like receptors 4 transforming growth factor β receptor I transforming growth factor β1 transmembrane protease serine protease 2 tumor necrosis factor utility Vaccine Vaccines vascular cell adhesion molecule vascular endothelial growth factor VCAMvascular cell adhesion molecule VEGFvascular endothelial growth factor
[DOI] 10.1016/j.phrs.2022.106334 [Article Type] Review article

Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility

종 내 및 종 간 SARS-CoV-2 전염성 예측 모델

Article

Published on 2022-07-192022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 complex Coronaviridae Coronaviridae family coronavirus enzyme expected feature host receptor hosts human ACE2 receptor humans in silico infect Infection interact interfacing residues Model Mutation pandemic Positive selection positively correlated predict predicted Prediction model Protein receptor complex replacement reported reservoir residue residues S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants shown species spike spike glycoprotein spike glycoprotein (S). subtype Subtypes susceptible the Coronaviridae the SARS-CoV-2 thought Transmissibility transmissibility of SARS-CoV-2 virus
[DOI] 10.3390/v14071565 PMC 바로가기 [Article Type] Article

High D-glucose levels induce ACE2 expression via GLUT1 in human airway epithelial cell line Calu-3

Article

Published on 2022-07-152023-07-10
Journal: BMC Molecular and Cell Biology
[Category] COVID19(2023년),

[키워드] ACE2 angiotensin converting enzyme 2 COVID-19 Glucose transporters SARS-CoV-2.
[DOI] 10.1186/s12860-022-00427-4 PMC 바로가기

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells
[Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells mesenchymal stem cells. MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Thrombosis and thrombocytopenia in COVID-19 and after COVID-19 vaccination

COVID-19 및 COVID-19 백신 접종 후의 혈전증 및 혈소판 감소증

Review

Published on 2022-07-012022-09-11
Journal: Trends in cardiovascular medicine
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system Adenovirus Adenovirus-vectored vaccine administration aggregation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antibody detection Antiplatelet factor cause Coagulation Coagulopathy condition coronavirus coronavirus disease COVID-19 COVID-19 vaccination Critical detect diagnosing Diagnosis Disease progression disease severity dysregulation effective ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay event false-positive rate false-positive rates hemophagocytic lymphohistiocytosis hemophagocytic syndrome immune Immune thrombocytopenic purpura Inflammation initial Interaction lupus erythematosus Messenger RNA mitigate occur optical optical density Pathogenesis PF4 Platelet platelet aggregation Platelets positive progression purpura SARS-CoV-2 serious complication severe acute respiratory syndrome Coronavirus Side effects Spike protein syndrome systemic lupus erythematosus the disease the patient thrombocytopenia thrombocytopenic purpura Thromboembolism thrombosis thrombotic Thrombotic thrombocytopenia Thrombotic thrombocytopenic purpura vaccination Vaccine vaccine. Vaccines vectored vaccine
[DOI] 10.1016/j.tcm.2022.02.008 PMC 바로가기 [Article Type] Review

Clinical progress in MSC-based therapies for the management of severe COVID-19

Mini review

Published on 2022-07-012022-10-05
Journal: Cytokine & growth factor reviews
[Category] COVID19(2023년), SARS, 바이오마커, 임상,

Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats

17β-estradiol이 수컷 쥐의 폐와 결장에서 ACE2, ADAM17, TMPRSS2 및 estradiol 수용체 전사의 일일 패턴에 미치는 영향

Article

Published on 2022-06-282022-09-11
Journal: PLoS ONE
[Category] COVID19(2023년), SARS, 유전자 메커니즘,